解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The single-span membrane protein KCNE3 modulates a variety of voltage-gated ion channels in diverse biological contexts. In epithelial cells, KCNE3 regulates the function of the KCNQ1 potassium ion (K(+)) channel to enable K(+) recycling coupled to transepithelial chloride ion (Cl(-)) secretion, a physiologically crit...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501228
更新日期:2016-09-09 00:00:00
abstract::Driven by advances in materials and computer science, researchers are attempting to design systems where the computer and material are one and the same entity. Using theoretical and computational modeling, we design a hybrid material system that can autonomously transduce chemical, mechanical, and electrical energy to...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1601114
更新日期:2016-09-02 00:00:00
abstract::Climate change threatens agricultural productivity worldwide, resulting in higher food prices. Associated economic gains and losses differ not only by region but also between producers and consumers and are affected by market dynamics. On the basis of an impact modeling chain, starting with 19 different climate projec...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501452
更新日期:2016-08-24 00:00:00
abstract::The formation of the Isthmus of Panama stands as one of the greatest natural events of the Cenozoic, driving profound biotic transformations on land and in the oceans. Some recent studies suggest that the Isthmus formed many millions of years earlier than the widely recognized age of approximately 3 million years ago ...
journal_title:Science advances
pub_type: 杂志文章,评审
doi:10.1126/sciadv.1600883
更新日期:2016-08-17 00:00:00
abstract::Meteorite impact craters are one of the most common geological features in the solar system. An impact event is a near-instantaneous process that releases a huge amount of energy over a very small region on a planetary surface. This results in characteristic changes in the target rocks, from vaporization and melting t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600616
更新日期:2016-08-05 00:00:00
abstract::Over the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells. Functional studies in model organisms and humans indicate that epigenetic changes have a huge influence on the aging process. These epigenetic chang...
journal_title:Science advances
pub_type: 杂志文章,评审
doi:10.1126/sciadv.1600584
更新日期:2016-07-29 00:00:00
abstract::Micrometer-scale acoustic waves are highly useful for refined optomechanical and acoustofluidic manipulation, where these fields are spatially localized along the transducer aperture but not along the acoustic propagation direction. In the case of acoustic tweezers, such a conventional acoustic standing wave results i...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600089
更新日期:2016-07-13 00:00:00
abstract::Cytosolic RNA sensing is a prerequisite for initiation of innate immune response against RNA viral pathogens. Signaling through RIG-I (retinoic acid-inducible gene I)-like receptors (RLRs) to TBK1 (Tank-binding kinase 1)/IKKε (IκB kinase ε) kinases is transduced by mitochondria-associated MAVS (mitochondrial antiviral...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501889
更新日期:2016-07-01 00:00:00
abstract::Weyl semimetals are of great interest because they provide the first realization of the Weyl fermion, exhibit exotic quantum anomalies, and host Fermi arc surface states. The separation between Weyl nodes of opposite chirality gives a measure of the robustness of the Weyl semimetal state. To exploit the novel phenomen...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600295
更新日期:2016-06-24 00:00:00
abstract::Gravel-bed river floodplains in mountain landscapes disproportionately concentrate diverse habitats, nutrient cycling, productivity of biota, and species interactions. Although stream ecologists know that river channel and floodplain habitats used by aquatic organisms are maintained by hydrologic regimes that mobilize...
journal_title:Science advances
pub_type: 杂志文章,评审
doi:10.1126/sciadv.1600026
更新日期:2016-06-24 00:00:00
abstract::The rapid growth of deformable and stretchable electronics calls for a deformable and stretchable power source. We report a scalable approach for energy harvesters and self-powered sensors that can be highly deformable and stretchable. With conductive liquid contained in a polymer cover, a shape-adaptive triboelectric...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501624
更新日期:2016-06-17 00:00:00
abstract::Continental rifting and seafloor spreading play a fundamental role in the generation of new crust. However, the distribution of magma and its relationship with tectonics and volcanism remain poorly understood, particularly in back-arc settings. We show evidence for a large, long-lived, off-axis magmatic intrusion loca...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600288
更新日期:2016-06-03 00:00:00
abstract::The importance of comets for the origin of life on Earth has been advocated for many decades. Amino acids are key ingredients in chemistry, leading to life as we know it. Many primitive meteorites contain amino acids, and it is generally believed that these are formed by aqueous alterations. In the collector aerogel a...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600285
更新日期:2016-05-27 00:00:00
abstract::Photonic crystal nanocavities, which have modal volumes of the order of a cubic wavelength in the material, are of great interest as flexible platforms for manipulating photons. Recent developments in ultra-high quality factor nanocavities with long photon lifetimes have encouraged us to develop an ultra-compact and f...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501690
更新日期:2016-05-20 00:00:00
abstract::Optogenetics is a paradigm-changing new method to study and manipulate the behavior of cells with light. Following major advances of the used genetic constructs over the last decade, the light sources required for optogenetic control are now receiving increased attention. We report a novel optogenetic illumination pla...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600061
更新日期:2016-05-06 00:00:00
abstract::Starvation is probably the most common stressful situation in nature. In vertebrates, elevation of the biogenic amine norepinephrine levels is common during starvation. However, the precise role of norepinephrine in nutrient deprivation remains largely unknown. We report that in the free-living nematode Caenorhabditis...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501372
更新日期:2016-05-06 00:00:00
abstract::Understanding the principles that led to the current complexity of the genetic code is a central question in evolution. Expansion of the genetic code required the selection of new transfer RNAs (tRNAs) with specific recognition signals that allowed them to be matured, modified, aminoacylated, and processed by the ribo...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501860
更新日期:2016-04-29 00:00:00
abstract::Two-dimensional (2D) semiconductors have shown great potential for electronic and optoelectronic applications. However, their development is limited by a large Schottky barrier (SB) at the metal-semiconductor junction (MSJ), which is difficult to tune by using conventional metals because of the effect of strong Fermi ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1600069
更新日期:2016-04-22 00:00:00
abstract::As one of the most prolific and widespread reef builders, the staghorn coral Acropora holds a disproportionately large role in how coral reefs will respond to accelerating anthropogenic change. We show that although Acropora has a diverse history extended over the past 50 million years, it was not a dominant reef buil...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500850
更新日期:2016-04-22 00:00:00
abstract::In May 2014, the Balkans were hit by a Vb-type cyclone that brought disastrous flooding and severe damage to Bosnia and Herzegovina, Serbia, and Croatia. Vb cyclones migrate from the Mediterranean, where they absorb warm and moist air, to the north, often causing flooding in central/eastern Europe. Extreme rainfall ev...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501428
更新日期:2016-04-15 00:00:00
abstract::Wogonin and baicalein are bioactive flavones in the popular Chinese herbal remedy Huang-Qin (Scutellaria baicalensis Georgi). These specialized flavones lack a 4'-hydroxyl group on the B ring (4'-deoxyflavones) and induce apoptosis in a wide spectrum of human tumor cells in vitro and inhibit tumor growth in vivo in di...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501780
更新日期:2016-04-08 00:00:00
abstract::G-quadruplex (G4) is one of the most important secondary structures in nucleic acids. Until recently, G4 RNAs have not been reported in any ribovirus, such as the hepatitis C virus. Our bioinformatics analysis reveals highly conserved guanine-rich consensus sequences within the core gene of hepatitis C despite the hig...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501535
更新日期:2016-04-01 00:00:00
abstract::Correlating spatial chemical information with the morphology of closely packed nanostructures remains a challenge for the scientific community. For example, supramolecular self-assembly, which provides a powerful and low-cost way to create nanoscale patterns and engineered nanostructures, is not easily interrogated in...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501571
更新日期:2016-03-25 00:00:00
abstract::By developing new computational models, we examine how enzymatic reactions on an underlying surface can be harnessed to direct the motion and organization of reagent-laden microcapsules in a fluid-filled microchannel. In the presence of appropriate reagents, surface-bound enzymes can act as pumps, which drive large-sc...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501835
更新日期:2016-03-18 00:00:00
abstract::Forest loss is one of the most pervasive land surface transformations on Earth, with drastic effects on global climate, ecosystems, and human well-being. As part of biodiversity conservation and climate change mitigation efforts, many countries, including China, have been implementing large-scale policies to conserve ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500965
更新日期:2016-03-18 00:00:00
abstract::Ice accretion has a negative impact on critical infrastructure, as well as a range of commercial and residential activities. Icephobic surfaces are defined by an ice adhesion strength τice < 100 kPa. However, the passive removal of ice requires much lower values of τice, such as on airplane wings or power lines (τice ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501496
更新日期:2016-03-11 00:00:00
abstract::Modern tropical forests harbor an enormous diversity of squamates, but fossilization in such environments is uncommon and little is known about tropical lizard assemblages of the Mesozoic. We report the oldest lizard assemblage preserved in amber, providing insight into the poorly preserved but potentially diverse mid...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501080
更新日期:2016-03-04 00:00:00
abstract::Gender inequality in contemporary U.S. society is a well-documented, widespread phenomenon. However, little is known about gender disparities in product markets. This study is the first to use actual market data to study the behavior of women and men as sellers and buyers and differences in market outcomes. We analyze...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500599
更新日期:2016-02-19 00:00:00
abstract::Skyrmions are topologically protected nanoscale magnetic spin entities in helical magnets. They behave like particles and tend to form hexagonal close-packed lattices, like atoms, as their stable structure. Domain boundaries in skyrmion lattices are considered to be important as they affect the dynamic properties of m...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501280
更新日期:2016-02-12 00:00:00
abstract::Since Darwin's conception of sexual selection theory, scientists have struggled to identify the evolutionary forces underlying the pervasive differences between male and female behavior, morphology, and physiology. The Darwin-Bateman paradigm predicts that anisogamy imposes stronger sexual selection on males, which, i...
journal_title:Science advances
pub_type: 杂志文章,评审
doi:10.1126/sciadv.1500983
更新日期:2016-02-12 00:00:00
abstract::Peptidyl arginine deiminase 4 (PAD4) is a nuclear enzyme that converts arginine residues to citrulline. Although increasingly implicated in inflammatory disease and cancer, the mechanism of action of PAD4 and its functionally relevant pathways remains unclear. E2F transcription factors are a family of master regulator...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501257
更新日期:2016-02-05 00:00:00
abstract::Modeling a complex system is almost invariably a challenging task. The incorporation of experimental observations can be used to improve the quality of a model and thus to obtain better predictions about the behavior of the corresponding system. This approach, however, is affected by a variety of different errors, esp...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501177
更新日期:2016-01-22 00:00:00
abstract::The role of sialyloligosaccharides on the surface of secreted glycoproteins is still unclear because of the difficulty in the preparation of sialylglycoproteins in a homogeneous form. We selected erythropoietin (EPO) as a target molecule and designed an efficient synthetic strategy for the chemical synthesis of a homo...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500678
更新日期:2016-01-15 00:00:00
abstract::Improved constraints on lower-mantle composition are fundamental to understand the accretion, differentiation, and thermochemical evolution of our planet. Cosmochemical arguments indicate that lower-mantle rocks may be enriched in Si relative to upper-mantle pyrolite, whereas seismic tomography images suggest whole-ma...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500815
更新日期:2015-12-10 00:00:00
abstract::Coordinatively unsaturated (CUS) iron sites are highly active in catalytic oxidation reactions; however, maintaining the CUS structure of iron during heterogeneous catalytic reactions is a great challenge. Here, we report a strategy to stabilize single-atom CUS iron sites by embedding highly dispersed FeN4 centers in ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500462
更新日期:2015-12-04 00:00:00
abstract::Intrinsic immune defenses mediated by restriction factors inhibit productive viral infections. Select viruses rapidly establish latent infections and, with gene expression profiles that imply cell-autonomous intrinsic defenses, may be the most effective immune control measure against latent reservoirs. We illustrate t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1501164
更新日期:2015-11-27 00:00:00
abstract::Redox flow batteries (RFBs) are considered one of the most promising large-scale energy storage technologies. However, conventional RFBs suffer from low energy density due to the low solubility of the active materials in electrolyte. On the basis of the redox targeting reactions of battery materials, the redox flow li...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500886
更新日期:2015-11-27 00:00:00
abstract::Microbial fuel cells (MFCs) are able to directly convert about 50 to 90% of energy from oxidation of organic matters in waste to electricity and have great potential application in broad fields such as wastewater treatment. Unfortunately, the power density of the MFCs at present is significantly lower than the theoret...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500372
更新日期:2015-11-13 00:00:00
abstract::Resistances that exceed the Mott-Ioffe-Regel limit (known as bad metal behavior) and non-Fermi liquid behavior are ubiquitous features of the normal state of many strongly correlated materials. We establish the conditions that lead to bad metal and non-Fermi liquid phases in NdNiO3, which exhibits a prototype bandwidt...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500797
更新日期:2015-11-06 00:00:00
abstract::The exceptionally long quantum coherence times of phosphorus donor nuclear spin qubits in silicon, coupled with the proven scalability of silicon-based nano-electronics, make them attractive candidates for large-scale quantum computing. However, the high threshold of topological quantum error correction can only be ca...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1500707
更新日期:2015-10-30 00:00:00